A collection of scientific literature describing the use of CultiSpher microcarriers. Please contact us if you have additions to this list.
| 2010 |  |
Engineering three-dimensional cartilage- and bone-like tissues using human dermal fibroblasts and macroporous gelatine microcarriers J. Plastic, Reconstructive & Aesthetic Surgery 63, 1036-1046, 2010 |
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Passive mechanical forces upregulate the fast myosin heavy chain IId/x via integrin and p38 MAP kinase activation in a primary muscle cell culture Am. J. Physiol. Cell Physiol 298, C910-C920, 2010 |
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Engineering dermal equivalent tissue in vitro by assembly of microtissue precursors Acta Biomaterialia 6, 2548-2553, 2010 |
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Biodegradable and injectable cure-on-demand polyurethan scaffolds for regeneration of articular cartilage Acta Biomaterialia 6, 3471-3481, 2010 |
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Slow cooling cryopreservation of cell-microcarrier constructs Cells Tissues Organs, 192, 177-186, 2010 |
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| Use of macroporous gelatine spheres as a biodegradable scaffold for guided tissue regeneration of healthy dermis in humans: An in vivo study Journal of Plastic, Reconstructive & Aesthetic Surgery , Volume 63, 848-857, 2010 |
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Evaluation of Bone Regeneration with an Injectable, In Situ Polymerizable Pluronic ® F127 Hydrogel Derivative Combined with Autologous Mesenchymal Stem Cells in a Goat Tibia Defect Model Tissue Engineering Part A. February 2010, 16(2): 617-627. |
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Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system. J. Biotechnol., 146(4), 194-7, 2010 |
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| 2009200 | |
| Human Dermal Fibroblasts: A Potential Cell Source for Endothelialization of Vascular Grafts Annals of Vascular Surgery , Volume 23,663-674, 2009 |
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Human articular chondrocytes on macroporous gelatin microcarriers form structurally stable constructs with blood-derived biological glues in vitro J. Tissue. Eng. Regen. Med. 3, 450-60, 2009 |
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Functional and phenotypic characterization of human keratinocytes expanded in microcarrier culture J. Biomed.Mater.Res. 88A, 184-94, 2009 |
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Global Transcriptome Analysis in Mouse Calvarial Osteoblasts Highlights Sets of Genes Regulated by Modeled Microgravity and Identifies A "Mechanoresponsive Osteoblast Gene Signature" J. Cell. Biochem. 107, 240-52, 2009 |
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The development of photochemically crosslinked native fibrinogen as a rapidly formed and mechanically strong surgical tissue sealant Biomaterials 30, 2059-2065, 2009 |
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Ear mesenchymal stem cells: An efficient adult multipotent cell population fit for rapid and scalable expansion J. Biotechnol. 139, 291-299, 2009 |
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| 20082008 | |
Attachment and growth of human embryonic stem cells on microcarriers J. Biotechnol. 138, 24-32, 2008 |
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Entrapment of Embryonic Stem Cells-Derived Cardiomyocytes in Macroporous Biodegradable Microspheres: Preparation and Characterization Cell. Physiol.Biochem. 22, 665-672, 2008 |
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Metabolic transformation of rabbit skeletal muscle cells in primary culture in response to low glucose BBA 1783, 813-825, 2008 |
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Functional and phenotypic characterization of human keratinocytes expanded in microcarrier culture J. Biomed. Mater. Res. 88A, 184-194, 2008 |
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| 2007 | |
Employing human keratinocytes cultured on macroporous gelatin spheres to treat full thickness-wounds: an in vivo study on athymic rats Burns 33, 726-735, 2007 |
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Mouse Embryonic Stem Cell Expansion in a Microcarrier-based Stirred Culture System J. Biotechnology 132, 227-236, 2007 |
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Collagenous Microbeds as a Scaffold for Tissue Engineering with Adipose-derived Stem Cells Plast. Reconstr. Surg. 120, 441-4241, 2007 |
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Comparison of Biodegradable Conduits within Aged Rat Sciatic Nerve Defects Plast. Reconstr. Surg. 119, 1839-1851, 2007 |
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Cost-effective Engineering of a Small-scale Bioreactor Biotechnol. & Bioeng. 96, 401-407, 2007 |
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Evaluating Kinetic and Physiological Features of rCHO-K1 Cells Cultured on Microcarriers for Production of a Recombinant Metalloprotease/Disintegrin Electronic J. Biotechnology 10, 200-210, 2007 |
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Macroporous Gelatine Spheres as Culture Substrate, Transplantation Vehicle, and Degradable Scaffold for Guided Regeneration of Soft Tissues. In Vivo Study in Nude Mice J. Plast. Reconstr. Aesthet Surg. 60, 543-555, 2007 |
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Ex Vivo Expansion of Rat Bone Marrow Mesenchymal Stromal Cells on Microcarrier Beads in Spin Culture Biomaterials 28, 3110-3120, 2007 |
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Gelatin-Based Microcarriers as Embryonic Stem Cell Delivery System in Bone Tissue Engineering: An In-Vitro Study Biomacromolecules 8, 825-832, 2007 |
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| 2006 | |
Microcarriers in the Engineering of Cartilage and Bone Trends in Biotechnol. 24, 299-304, 2006 |
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Process Development for the Mass Production of Ehrlichia ruminantium Vaccine 24, 1716-1725, 2006 |
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High Yields of Autologous Living Dermal Equivalents Using Porcine Gelatin Microbeads as Microcarriers for Autologous Fibroblasts Cell Transplantation 15, 445-451, 2006 |
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A Novel Bioreactor Microcarrier Cell Culture System for High Yields of Proliferating Autologous Keratinocytes Cell Transplantation 15, 435-443, 2006 |
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Expansion of Chondroprogenitor Cells on Macroporous Microcarriers as an Alternative to Conventional Monolayer Systems Biomaterials 27, 2970-9, 2006 |
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| 2005 | |
Encapsulation of osteoblast seeded microcarriers into injectable, photopolymerizable three-dimensional scaffolds based on D,L-lactide and epsilon-caprolactone Biomacromolecules 6(3), 1608-1614, 2005 |
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Evaluation of Polymer Scaffolds to be used in a Composite Injectable System for Intervertebral Disc Tissue Engineering J. Biomed. Mater. Res. 74A, 32-39, 2005 |
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Artificial Tumour Model Suitable for Monitoring 31P and 13C NMR Spectroscopic Changes During Chemotherapy-Induced Apoptosis in Human Glioma Cells Magn. Res. Med. 54, 67-78, 2005 |
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Evaluation of Polymer Scaffolds to be Used in a Composite Injectable System for Invertebral Disc Tissue Engineering J. Biomed. Mater. Res. 74A, 32-39. 2005 |
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Intrastriatal Implantation of Human Retinal Pigment Epithelial Cells Attached to Microcarriers in Advanced Parkinson Disease Arch. Neurol. 62, 1833-1837, 2005 |
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| 2004 | |
Interactions Between Intracellular Chloride Concentrations, Intracellular pH and Energetic Status in Rat Lactotrope Cells in Primary Culture Gen. Physiol. Biophys. 23, 195-208, 2004 |
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Bioreactor Microcarrier Cell Culture System (Bio-MCCS) for Large-Scale Production of Autologous Melanocytes Cell Transplantation 13, 809-816, 2004 |
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PET Imaging of Implanted Human Retinal Pigment Epithelial Cells in the MPTP-induced Primate Model of Parkinson´s Disease Exp. Neurol. 189, 362-368, 2004 |
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Autologous Cultured Keratinocytes on Porcine Gelatin Microbeads Effectively Heal Cronic Venous Leg Ulcers Wound Repair and Regen. 12:2, 148-156, 2004 |
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Muti-channeled biodegradable polymer/CultiSpher composite nerve guides Biomaterials 25, 1269-1278, 2004 |
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Rabies Virus Production in High Vero Cell Density Cultures on Macroporous Microcarriers Biotechnol. Bioeng. 85, 506-515, 2004 |
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| 2003 | |
Ca 2+ Transients Activate Calcineurin/NFATc1 and Initiate Fast-to-slow Transformation in a Primary Skeletal Muscle Culture Am. J. Physiol. Cell Physiol. 285, C56-C63, 2003 |
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Contribution of the Phosphorylable Complex I in the Growth Phase-Dependent Respiration of C6 Glioma Cells in Vitro J. Bioenergetics Biomembranes 35, 439-450, 2003 |
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Stereotaxic Intrastriatal Implantation of Human Retinal Pigment Epithelial (hRPE) Cells Attached to Gelatin Microcarriers: a Potential New Cell Therapy for Parkinson´s Disease J. Neural. Transm. (Suppl.) 65, 215-227, 2003 |
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Expansion of human nasal chondrocytes on macroporous microcarriers enhances redifferentiation J. Biomaterials 24, 5153-5161, 2003 |
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Using PC12 Cells to Evaluate Poly(caprolactone) and Collagenous Microcarriers for Application in Nerve Guide Fabrication Biotechnol. Prog. 19, 1767-1775, 2003 |
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ATP Generation in the Trypanosoma brucei Procyclic Form J. Biol.Chem. 278:49, 49625-49635, 2003 |
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| 2002 | |
Ex vivo expansion of human umbilical cord blood hematopoietic progenitor cells in a novel three-dimensional culture system Biotechnol. Lett. 24, 1421-1426, 2002 |
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Na+/H+ exchange subtype 1 inhibition during exytacellular acidification and hypoxia in glioma cells J. Neurochem. 80, 36-44, 2002 |
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Microcarrier Culture of Lepidopteran Cell Lines: Implications for Growth and Recombinant Protein Production Biotechnol. Progr. 18, 1345-1355, 2002, |
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Multinuclear NMR Studies of an Actively Dividing Artificial Tumour Physiol. Res. 51, 49-58, 2002 |
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Process Development for Fuctional Membrane Receptor Production in Mammalian Cells Cytotechnology 38, 109-117, 2002 |
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Fast-To-Slow Transformation and Nuclear Import/Export Kinetics of the Transcription Factor NFATc1 During Electrostimulation of Rabbit Muscle Cells in Culture J. Physiol. 541.3, 835-847, 2002 |
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| 2001 | |
Effect of Ethanol on the Metabolism of Primary Astrocytes Studied by 13C- and 31P-NMR Spectroscopy J. Neurosci. Res. 66:5, 803-811, 2001 |
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Entrapment of Dispersed Pancreatic Islet Cells in CultiSpher-S Macroporous Gelatin Microcarriers: Preparation, In Vitro Characterization, and Microencapsulation Biotech. Bioeng. 75:6, 741-744, 2001 |
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Calcineurin Regulates Slow Myosin, but not Fast Myosin or Metabolic Enzymes, During Fast-To-Slow Transformation in Rabbit Skeletal Mucle Cell Culture J. Physiol. 533.1, 215-226, 2001 |
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| 2000 | |
High-Resolution Elasticity Imaging for Tissue Engineering IEE Transaction on Ultrasonics, Ferroelectrics and Frequency Control 47, 956-966, 2000 |
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Development of a rapid and sensitive bioassay using human cells immobilized in macroporous microcarriers for on-site evaluation of environmental waters Appl. Microbiol.Biotechnol. 54, 432-438, 2000 |
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Cultivation of Immortalized Human Hepatocytes HepZ on Macroporous CultiSpher-G Microcarriers Biotech. Bioeng. 68:1, 59-70, 2000 |
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Culture and Function of Electrofusion-Derived Clonal Insulin-Secreting Cells Immobilized on Solid and Macroporous Microcarrier Beads Bioscience Repoports 20:3, 167-176, 2000 |
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Assessing a Disposable Bioreactor for Attachment-Dependent Cells http://www.wavebiotech.com/pdfs/literature/biopharmfeb2000.pdf |
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| 1999 | |
Production of reovirus type-1 and type-3 from Vero cells grown on solid and macroporous microcarriers Biotechnol Bioeng. 62, 12-19 1999 |
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An Integrated Strategy for the Process Development of a Recombinant Antibody-Cytokine Fusion Protein Expressed in BHK Cells Appl. Microbiol. Biotechnol. 52, 345-353 1999 |
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| Cell Growth and Protein Formation
on Various Microcarriers Cytotechnology 29, 149-156 1999 |
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| Immobilization of Pancreatic Islet Cells with Preserved
Secretory Potential Appl. Microbiol. Biotechnol. 52, 652-653 1999 |
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| A Microcarrier-based Cell Culture Process for the
Production of a Bovine Respiratory Syncytial Virus Vaccine Cytotechnology 29, 135-148 1999 |
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| Intracranial Tolerability of Spheramine (Gelatin
Microcarrier-bound Human Retinal Pigment Epithelial (hRPE) Cells)
and Gelatin Microcarriers in Cynomolgus Monkey Society for Neurosciences Abstracts Vol 25, Part 1 29th Annual Meeting, Miami beach, Fla, October 23-28, 1999 |
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| Growth of Human Tumour Cells in Macroporous Microcarriers
Results in p53-Independent, Decreased Cisplatin Sensitivity Relative
to Monolayers |
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| Cultivation and Characterization of a New Immortalized
Human Hepatocyte Cell Line, Hepz, for Use in an Artficial Liver Support
System Ann N Y Acad Sci. Jun 18;875,364-8 1999 |
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| 1998 | |
| Performance Study of Perfusion Cultures for the Production
of Single.Chain Urokinase.Type Plasminogen Activator (scu-PA) in a
2.5 l Spin-Filter Bioreactor Bioprocess Eng. 19, 363-372 1998 |
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| Study of Different Cell Culture Conditions for the
Production of a "Reshaped" MAB in NSO Cells In New Developments and New Applications in Animal Cell Technology. Kluwer Academic Publishers. 51-53 1998 |
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| 1997 | |
| Adult fast myosin pattern and Ca2+-induced slow myosin
pattern in primary skeletal muscle culture Proc. Natl. Acad. Sci. USA 94, 4205-4210 1997 |
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| Topgraphical Imaging of Macroporous Microcarriers In Animal Cell Technology: Basic & Applied Aspects. Kluwer Academic Publishers. 8, 89-94 1997 |
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| Infiltration and Lysis of Tumour Cell Aggregates
by Adherent Interleukin-2-Activated Natural Killer Cells is Distinct
from Specific Cytolysis |
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| Increasing GPI-Anchored Protein Harvest Concentrations
from Suspension and Porous Microcarrier CHO Cell Cultures Biotech. Bioeng. 55, 136-147 1997 |
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| Cell Propagation is Overestimated by the Crystal
Violet Nuclei Counting Technique In Animal Cell Technology. Kluwer Academic Publishers. 461-466 1997 |
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| Process Control of Antithrombin III Production by
Near-infrared Spectroscopy In Animal Cell Technolgy. Kluwer Academic Publishers. 417-421 1997 |
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| Immobilisation of Primary Brain Cells in Porous Microcarriers
for On Line NMR Spectroscopy In Animal Cell Technology. Kluwer Academic Publishers. 91-98 1997 |
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| Three-dimensional Cell Culture Systems Stabilize
the Differentiation of Hepatocyte Cell Lines. In Animal Cell Technology. Kluwer Academic Publishers. 115-119 1997 |
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| The Effect of Cell Culture Systems in the Phenotypic
Stability in Primary Hepatocyte Cells In Animal Cell Technology. Kluwer Academic Publishers. 145-149 1997 |
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| 1996 | |
| Immobilization of Primary Astrocytes and Neurons
for On-Line Monitoring of Biochemical Processes by NMR Dev. Nerosci. 18, 478-483 1996 |
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| The Use of Macroporous Microcarriers for the Large-Scale
Growth of V79 Cells Genetically Designed to Express Single Human Cytochrome
P450 Isoenzymes and for the Characterization of the Expressed Cytochrome
P450 Protein Expr. Purif. 8, 439-446 1996 |
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| Topographical Imaging of Macroporous Microcarriers
Using Laser Scanning Confocal Microscopy J. Fermen. Bioeng. 81, 437-444 1996 |
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| Confocal Laser Scanning Microscopy Examination of
Cell Distribution in Macroporous Microcarriers Biotechnol. Prog. 12, 398-402 1996 |
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| Growth and Radiation Responce of Cells Grown in Macroporous
Gelatin Microcarriers(CultiSpher-G) Brit. J. Cancer. Suppl. XXVII, S-78-S82 1996 |
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| Optimization of Physical Parameters for Cell Attachment
and Growth on Macroporous Microcarriers Biotech. Bioeng. 50, 627-635 1996 |
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| Two-dimensional Versus Three-dimensional Culture
Systems: Effects on Growth and Productivity of BHK Cells Biotech. Bioeng. 52, 429-432 1996 |
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| 1995 | |
| The Use of Microcarrier Beads in Ion Transport NMR
Studies of Perfused Cells J.Magnetic Res. 108, 81.85 1995 |
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| Membrane Anchored Protein Production from Spheroid,
Porous and Solid Microcarrier Chinese Hamster Ovary Cell Cultures Biotech. Bioeng. 47, 550-556 1995 |
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| Influence of the Culture System Upon Growth and Productivity
of Animal Cells in Stirred Systems In Animal Cell technology: Developments towards the 21st Century. Kluwer Academic Publishers. 105-109 1995 |
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| Microcarrier Technology, Present Status and Perspective In Animal Cell technology: Developments towards the 21st Century. Kluwer Academic Publishers. 899-904 1995 |
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| 1994 | |
| Intraocular Bioassay of a Pronephric Tumour Cell
Line Cultivated on Macroporous Microcarrier Beads In Vitro Cell. Dev. Biol. 30A, 85-86 1994 |
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| Expansion of Hematopoietic Progenitor Cell Populations
in Stirred Suspension Bioreactors of Normal Human Bone Marrow Cells Bio/Technology. 14, 909-914 1994 |
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| Glycolipid Membrane Anchored Recombinant Protein
Production from CHO Cells Cultures on Porous Microcarriers Biotech. Bioeng. 44, 45-54 1994 |
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| Measurements of the Growth and Distribution of Mammalian
Cells in a Hollow-Fiber Bioreactor Using Nuclear Magnetic Resonance
Imaging Bio/Technology 12, 75-78 1994 |
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| Cerebral Neurons, Skeletal Myoblasts, and Cardiac
Muscle Cells Cultures on Macroporous Beads Biotech. Bioeng. 43, 826-831 1994 |
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| Bead-to-bead Transfer of Chinese Hamster Ovary cells
Using Macroporous Microcarriers Cytotechnology 14, 67.80 1994 |
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| 1993 | |
| High-level Expression of Recombinant Human Soluble
Thrombmodulin in Serum-free Medium by Cho-K1 Cells Appl. Microbiol. Biotechnol. 38, 520-525 1993 |
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| Evaluation of Anchorage-dependent Cell Propagation
Systems for Production of Human Acetylcholinesterase by Recombinant
293 Cells Cytotechnology 13, 115-123 1993 |
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| Anchorage-dependent Animal Cell Culture by Using
a Porous Microcarrier Bioprocess. Eng. 8, 295-299 1993 |
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| Growth of Human Vascular Endothelial Cells on Various
Types of Microcarriers Cytotechnology 13, 203-211 1993 |
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| 1992 | |
| Cultivation of Mammalian Cells on Macroporous Microcarriers Enzyme. Microb. Technol. 14, 203-208 1992 |
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| A Novel Microcarrier Bead Model to Investigate Bone
Cell Responses to Mechanical Compressions in Vitro J Bone Min. Res. 7, Supp. 2, S403-S405 1992 |
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| Efficient Serial Propagation of WI38 Cells on Porous
Microcarriers(CultiSpher-GL) Animal Cell Technology: Developments, Processes & Products. Butterworth-Heinemann Ltd. 508-510 1992 |
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| Dissolved Oxygen - The Critical Parameter at Cell
Growth and Expression of r-Protein in a Porous Microcarrier System Animal Cell Technology: Developments, Processes & Products. Butterworth-Heinemann Ltd. 212-214 1992 |
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| High Density BHK Culture Using Porous Microcarriers Animal Cell Technology: Developments, Processes & Products. Butterworth-Heinemann Ltd. 480-487 1992 |
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| 1991 | |
| CultiSpher-Macroporous Gelatin Microcarriers- New
Applications In Production of Biologicals from Animal cells in Culture. Butterworth-Heinemann Ltd. 434-438 1991 |
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| Comparison of Two Systems Based in Porous Beads
for the Production of Recombinant Von Willebrand Factor by CHO Cells In Production of Biologicals from Animal cells in Culture. Butterworth-Heinemann Ltd. 525-527 1991 |
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| Animal Cell Bioreactors - Recent Advances and Challenges
to Scale-Up Canad. J. Chem. Eng. 69, 409-420 1991 |
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| Improved Microscopic Observation of Mammalian Cells
on Microcarriers by Fluorescent Staining Cytotechnology 5, 141-146 1991 |
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| 1990 | |
| Production of Recombinant Von Willebrand Factor by
CHO Cells Cultured in Macroporous Microcarriers Cytotechnology 4, 163-171 1990 |
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| Biomaterials Aspects of Porous Microcarriers
for Animal Cell Culture |
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| The Use of Macroporous Gelatin carriers For the Cultivation
of Mammalian Cells in Fluidised Bed Reactors Cytotechnology 3, 271-277 1990 |
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| Growth of Cells on Macroporous Microcarriers In Trends in Animal Cell Culture Technology. VCH Publishers. 35-40, 1990 |
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| Immobilization of Animal Cells in Porous Carrier
Culture TIBTECH 8, 204-209 1990 |
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| 1987 | |
| Macroporous Microcarriers In Modern Approaches to Animal Cell Technology. Butterworth & Co. Ltd. 492-503 1987 |
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| 1986 | |
| Growth of Anchorage Dependent Cells on Macroporous
Microcarriers Bio/Technology 4, 989-990 1986 |